기관지 천식의 주요 증상은 천명과 호흡곤란이다.
천식 환자의 백혈구에서 산화적 스트레스를 나타내는 과산화 생성량과 지질 과산화 생성물이 증가함을 발견했다.
아스코르브산은 자유 라디칼을 직접적으로 중화시키는 중요한 항산화제로 천식 환자의 폐에서 산화 환원 상태를 유지하기 위해 지속해서 사용된다.
해치 박사 등은 아스코르브산이 폐의 기도 표면 내벽에 존재하는 주요 항산화 물질이며 내인성 및 외인성 산화제로부터 보호한다고 밝혔다.
본 연구를 통해 천명 증상이 있는 소아의 아스코르브산 수치가 낮은 것을 발견하였고, 이는 산화 라디칼이 계속하여 생성되는 것을 억제하고 외인성 산화제를 중화시키기 위한 정상적인 생리 기능과 그에 따른 이용률 증가 때문일 것으로 보인다.
그러므로, 아스코르브산 결핍은 천식의 병태 생리학 관점에서 볼 때 근본적인 요소이거나 기도 염증에 대한 반응일 수 있다.
연구자들이 플라즈마 아스코르브산 수치의 감소가 신체의 방어 메커니즘 유지와 조직의 무결성, 교체 및 치유 과정에서의 역할을 포함한 정상적인 생리적인 기능 때문이라고 설명한 점에서, 천명 증상이 있는 소아의 아스코르브산 수치가 낮다는 연구 결과도 이전의 보고와 같은 맥락으로 이해될 수 있다.
감기에 걸리는 동안 호흡 점막이 파괴되고 결과적으로 아스코르브산 수치가 감소하면서 점막 표면이 치유되는 것을 더욱 지연 시켜 천식의 장기 증상을 유발할 수 있다.
한 연구는 천식 환자는 심지어 무증상 기간 동안에도 항산화 비타민의 혈청 수치가 감소한다고 보고했다.
그 결과, 이러한 감소가 지질 과산화 생성물로 알 수 있는 산화적 스트레스의 증가와 직접적으로 연관이 있는 것은 아님을 알 수 있다.
Wheezing and shortness of breath are main symptoms of bronchial asthma. Asthmatics showed increased superoxide generation from leucocytes, as well as increased lipid peroxidation product, indicating increased oxidative stress. Ascorbic acid directly neutralizes free radical, thus it is continuously utilized to maintain the redox state of lung in asthma. Hatch et al suggested that ascorbic acid is the major antioxidant substance present in the airway surface lining of the lung, and may protect against endogenous as well as exogenous oxidants. Our present finding that low ascorbic acid caused wheezing in children could be attributed to its normal physiological function, elevated utilization to overcome continuous generation of oxidant radical and also to neutralize the exogenous oxidant. It has been suggested that ascorbic acid deficiency may be either an underlying factor in the pathophysiology of asthma or a response to asthmatic airways inflammation. Our findings of low ascorbic acid in wheezing children is in agreement with the earlier reports of researchers who attributed such kind of lowering in ascorbic acid level in plasma to its normal physiological function i.e., its utilization in the maintenance of defense mechanism, tissue integrity and replacement and healing process. Destruction of respiratory mucous membrane during common cold and resulting reduction of the tissue ascorbic acid, may further delay in the healing of mucous membrane surface leading to prolonged symptoms of asthma. A study shows that antioxidant vitamins are decreased in the sera of asthmatic patients even during the asymptomatic periods of the disease, and thus this decrease is not totally dependent on the increased oxidative stress as reflected by lipid peroxidation products.
Wheezing andshortness of breath are main symptoms of bronchial asthma. Asthmatics showedPatients with asthma show1 increased superoxide generation from leucocytesleukocytes,as well as increased lipid peroxidation product, indicatingboth of whichindicate increased oxidative stress. Ascorbic acid an important antioxidative 2directly neutralizes free radical, thus itis continuously utilizedused to maintain the a redoxstate oflung in the lungs of patients with 3asthma.Hatch et al.suggested that ascorbic acid is the major antioxidant substance present inthe airway surface liningliquid4 of the lung,and may protect against endogenous as well as exogenous oxidants. Our presentfinding thatof the low ascorbic acid causedlevel in children with5 wheezing in children couldmay be attributed toits normal physiological function, elevated utilization to overcome the continuousgeneration of oxidant radical and also and to neutralize theexogenous oxidant. It has been suggested that ascorbic acid deficiency may be either anunderlying factor in the pathophysiology of asthma or a response to asthmaticairwaysairway inflammation. Our present findingsof lowascorbic acid levels in children with wheezingchildrenis are in agreement with the earlierreportsof, wherein researchers who attributedsuch kindof loweringthe decrease in the plasma ascorbicacid level inplasma to its normal physiological function i.e.,functions,including its utilizationroles in maintaining themaintenanceof body’s defense mechanism, tissue and in the integrity and,replacement and healing process. processes of tissues. 6Destructionof the respiratorymucous membrane during common cold and resulting reduction ofinthe tissueascorbic acid, level in the tissue 7mayfurther delay in the healing of the mucous membranesurface,leading to prolonged symptoms of asthma. A study shows that serum levels of antioxidantvitamins aredecreaseddecrease in the sera of asthmatic patientswithasthma, even during the asymptomatic periods of thedisease, and thus this decrease is not totally dependent on the increasedoxidative stress, as reflected by lipid peroxidationproducts.
Wheezing Bronchia asthma mainly manifests as wheezing 1and shortness of breath are main symptoms of bronchial asthma. Asthmatics showedPatients with asthma show2 increased superoxide generation from leucocytesleukocytes, as well as and increased lipid peroxidation products, indicatingboth of which indicateincreased oxidative stress. Ascorbic acid is an important antioxidative 3that directly neutralizes free radicals; thustherefore,it is continuously usually 4utilizedused to maintain the a redoxstate of lung in the lungs of patients with 5asthma. According to Hatch et al. suggested that., ascorbic acidis the major antioxidant substance presentin the airway surface liningliquid6 of the lungs, and may protect against endogenous as well as and exogenousoxidants. Our present findingWe found that the presence of a that of the low ascorbic acid causedlevel in children with7 wheezing in children couldmay be attributed to its normal physiological function, and elevatedincreased utilization to overcome the continuous generation of oxidantradicals8 and also and9 to neutralize the exogenous oxidants.It has been suggested that Therefore10 ascorbic acid deficiency may be either anunderlying factor in the pathophysiology of asthma or a response to asthmatic airways11airway inflammation. Our in patients with asthma. Consistent with our present findings of , other studies have also reported a low ascorbic acid levels in children with wheezing; children is are inagreement with the earlier reports of,wherein these researchers havewho attributedsuch kindof loweringthe decrease in the plasma ascorbic acid level in plasma to its normal physiological function i.e.,functions, including its in maintaining the utilizationrolesmaintenance of body’s defense mechanism,tissue and in the integrity and,replacement and healing process. 12processes of tissues. 13Destruction of the respiratorymucous membrane during common cold and resulting reduction the consequent decrease in tissue ascorbic acidofin, level14s in the tissue mayfurther delay in the healing of the mucous membrane surface,leadingand result in to prolonged asthma symptoms of asthma. A study shows that reported decreased serum levels of antioxidant vitamins are decreaseddecrease in the sera of asthmatic patients with asthma, even during the asymptomaticperiods of the disease, and thus.Therefore,15 this decrease is does not totally dependentcompletelydepend on the increased oxidative stress, as reflected bylipid peroxidation products.
Bronchial asthma mainly manifests as wheezing and shortness of breath. Patients with asthma show increased superoxide generation from leukocytes and increased lipid peroxidation products, both of which indicate increased oxidative stress. Ascorbic acid is an important antioxidant that directly neutralizes free radicals; therefore, it is usually used to maintain a redox state in the lungs of patients with asthma. According to Hatch et al., ascorbic acid is the major antioxidant in the airway surface liquid of the lungs and may protect against endogenous and exogenous oxidants. We found that the presence of a low ascorbic acid level in children with wheezing may be attributed to its normal physiological function and increased utilization to overcome the continuous generation of oxidant radicals and to neutralize exogenous oxidants. Therefore, ascorbic acid deficiency may be an underlying factor in the pathophysiology of asthma or a response to airway inflammation in patients with asthma. Consistent with our findings, other studies have also reported a low ascorbic acid level in children with wheezing; these researchers have attributed the decrease in the plasma ascorbic acid level to its normal physiological functions in maintaining the body’s defense mechanism and in the integrity, replacement, and healing processes of tissues. Destruction of the respiratory mucous membrane during common cold and the consequent decrease in tissue ascorbic acid levels may further delay the healing of the mucous membrane surface and result in prolonged asthma symptoms. A study reported decreased serum levels of antioxidant vitamins in patients with asthma, even during the asymptomatic period of the disease. Therefore, this decrease does not completely depend on increased oxidative stress, as reflected by lipid peroxidation products.
